Electroneurography - Electromyography - Electroencephalography - Evoked potentials

The database contains thousands of patients, both adults and children

Used systems: Micromed Brainquick, Medtronic Keypoint 4, EMS Pegasus, EMS Surpass II, EMS Surpass LT, Carefusion NicOne

2005-2007 Pediatric Neurology Clinic -  Clinical Emergency Hospital for Children Cluj-Napoca

2007-2012 Neurology Clinic - Cluj County Emergency Hospital

2012-        Neurology Department - Municipal Clinical Hospital Cluj-Napoca

Coma monitoring

Recently initiated

Used system: Carefusion NicOne

2012-        Neurology Department - Municipal Clinical Hospital Cluj-Napoca

Intraoperative monitoring

Tens of patients

Used systems: Medtronic Keypoint 4, EMS Surpass II, EMS Surpass LT, Xltek Protektor

               2010-        Neurology Department - Municipal Clinical Hospital Cluj-Napoca

2013-        Neurosurgery Clinic - Cluj County Emergency Hospital



Member - FARMACYP - Pharmacogenomic implications of genes CYP2C9, CYP2C19 and MDR1 polymorphisms in antiepileptic drugs therapeutic efficacy evaluation in idiopathic epilepsy - nr. 41-082, 2007-2010

Member - TROMBOGEN -Pharmacogenomic impact of the determination of VKORC1 and CYP2C9 genes over the efficacy, safety and costs of the anticoagulant treatment – nr. 42-127, 2008-2011

Member - ERIC - Ascertaining the mechanism of fine-tuning of the immune response in the human tumoral and inflammatory pathology in order to find innovative therapies. - nr. 42-147, 2008-2011

Director - The disease-modifying pharmaco-therapy induced expression of immunomodulatory receptors in relapsing-remitting multiple sclerosis - 27020/44/15.11.2011., 2011-2012

Mentor - Comparison of electrophysiologic parameters in Myasthenia gravis patients with or without antibodies to acetylcholine receptors or muscle-specific tyrosine kynase, before and after treatment with pyrido-/neostigmine – 22714/27/06.10.2011., 2011-2012

Mentor - Immunomodulatory receptor expression in the CSF of multiple sclerosis patients - 22714/46/06.10.2011., 2011-2013

Relevant articles in the field:

Sandor Vl, Craciun C, Major ZZs, Voştinaru O, Tamas M. Effects of HYPERICUM PERFORATUM L. Alcoholic extract on reserpine immobility in open field test in the rat. Romanian Biological Sciences. 2007;5(1-2) :116-118.

Buzoianu AD, Bocsan IC, Militaru FC, Major ZZs. The effects of topiramate on acute anxiety models in rats. Eur Neuropsychopharm. 2008;18(Suppl 4):S502-503

Bocsan IC, Buzoianu AD, Militaru CF, Major ZZs. The influence of lamotrigine on rat behaviour. Basic Clin Pharmacol. 2009;105:148

Tomescu-Baciu A, Krausz LT, Major ZZs. Immune receptor and cytokine expression in PMBC of Multiple Sclerosis patients. Romanian Journal of Biochemistry. 2009;46(Supplementa):69.

Major ZZs, Benga I. Treatment options in ADHD. Clujul Medical. 2009;82(4):484-487.

Banias-Palaghita L, Major ZZs, Catana C, Krausz TL, Vl Sandor. Terapia cu fumaraţi în scleroza multiplă. Medicina moderna. 2009;16(Suppl1):65-67.

Meszaros I, Krausz TL, Fischer FE, Major ZZs, Popescu O. Expression of immunomodulatory genes in inflammatory and autoimmune diseases. Romanian Biotechnological Letters. 2010;6:5729-37

Major ZZs, Benga I. Stimulus related potentials in ADHD-epilepsy comorbidity in children. Preliminary report. Clujul Medical. 2010;83(2):313-317.

Bocsan C, Major ZZs, Maier C, Popp R, Iuga C, Trifa A, Militaru FC, Buzoianu AD. Study of the phenotypic variation expression in the metabolizing status of Romanian epileptic patients. Therapeutics Pharmacology and Clinical Toxicology. 2010;3:224-28.

Major ZZs, Buzoianu AD, Perju-Dumbrava L, Marginean I, Bocsan IC, Major KA. QEEG: Relative power findings in epilepsy. Therapeutics Pharmacology and Clinical Toxicology. 2010;4:269-73.

Major ZZs, Buzoianu AD, Perju-Dumbravă L, Mărginean I, Krausz LT, Văcăraş V et al. The effect of epilepsy on the age-related prolongation of the P300. Fiziologia/Physiology. 2010;20(4):24-7.

Şandor Vl, Danciu MM, Major ZZs, Gheban D, Sabin O, Butură A, Trîmbiţaş S. Histo-chemical changes produced by reserpine and dopamine in the adrenal medulla. Therapeutics pharmacology and clinical toxicology. 2010;14(Supplement 3):37.

Buzoianu AD, Bocşan IC, Maier C, TrifaAP, Popp RA, Perju Dumbrava L, Sabin O, Militaru C, Brusturean E, MajorZZs, Popescu O. Genotype-phenotype correlations between the alleles of the MDR1 C3435T polymorphism and pharmacokinetic parameters in Romanian epileptic patients. Therapeutics Pharmacology and Clinical Toxicology. 2011;1:40-44.

Vacaras V, Major ZZs, Buzoianu AD. Disease modifying pharmacological approach of multiple sclerosis. A focus on Glatiramer acetate. Therapeutics Pharmacology and Clinical Toxicology. 2011;15(4):265-69.

Bocsan IC, Buzoianu AD, Major ZZ et al. The MDR1 C3435T polymorphism and valproic acid plasmatic level in Romanian epileptic patients. Eur Neuropsychopharm. 2011;21(Suppl 3):S287-S287

Buzoianu AD, Bocsan IC, Maier C, Trifa AP, Militaru FC, Dumbrava LP, Major ZZ. Genotype phenotype correlations between the CYP2C19 polymorphysm and pharmacokinetic parameters in romanian epileptic patients. Eur Neuropsychopharm. 2011;21(Suppl 3):S284-S284

Major ZZs. Combined Evoked potentials in co-occuring ADHD and Epilepsy. Ideggyogy Sz. 2011;64(7–8):248–56

Krausz LT, Fischer-Fodor E, Major ZZs, Fetica B. GITR-expressing regulatory T-cell subsets are increased in tumor-positive lymph nodes from advanced breast cancer patients as compared to tumor-negative lymph nodes. Int J Immunopathol Pharmacol. 2012;25(1):59-66.

Vacaras V, Major ZZs, Buzoianu AD. One year on glatiramer acetate. Preliminary report on disease activity and disability evolution. HVM Bioflux . 2012;4(3):107-109.

Axente DD, Silaghi H, Silaghi CA, Major ZZs, Micu CM, Constantea NA.Operative outcomes of robot-assisted transaxillary thyroid surgery for benign thyroid disease: early experience in 50 patients. Langenbecks Arch Surg. 2013 May 23. [Epub ahead of print]

Axente DD, Major ZZs, Micu CM, Constantea NA. Technical Particularities of the Robot-Assisted Trans-Axillary Thyroidectomy. Chirurgia. 2013;108(3):422-28

Major ZZs, Văcăraş V, Buzoianu AD, Mureşanu DF. Glatiramer acetate treatment-related effects on visual EPs and P300 wave in patients suffering from multiple sclerosis. Neurophysiology. 2013;45(3):234-242.

Krausz LT, Major ZZs, Muresanu FD, Chelaru E, Nocentini G, Riccardi C.Characterization of CD4+ and CD8+ Tregs in a Hodgkin’s lymphoma patient presenting with myasthenia-like symptomsIdeggyogy Sz. 2013;66(9–10):343–348.

Vacaras V, Major ZZ, Seewooram R, Major KA, Muresanu DF, Buzoianu AD. Disease activity and disability evolution under glatiramer acetate: A clinical approach. Neuropsychopharmacol Hung. 2014 Mar;16(1):11-18.